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Choroidal schwannoma.

Sang-Hyeok Lee1, Jeong-Seok Hong, Joon-Hyuk Choi

  • 1Department of Ophthalmology, College of Medicine, Yeungnam University, Deagu, Korea. shhlll@lycos.co.kr

Acta Ophthalmologica Scandinavica
|January 7, 2006
PubMed
Summary
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This case study describes a rare intraocular schwannoma of the choroid. Definitive diagnosis required extensive pathological examination, highlighting challenges in differentiating it from other choroidal tumors.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Intraocular tumors, particularly those originating from the uveal tract, are uncommon.
  • Schwannoma is a rare type of tumor that can arise from the uveal tract, presenting diagnostic challenges.

Observation:

  • A 74-year-old woman presented with decreased visual acuity and proptosis.
  • Enucleation of the eyeball was performed for diagnostic evaluation of the choroidal tumor.

Findings:

  • Microscopic examination revealed a tumor composed of Antoni A (cellular solid) and Antoni B (loose myxoid) components.
  • Immunohistochemical analysis showed positive S-100 protein expression.
  • Ultrastructural examination identified tumor cells with prominent, continuous basal lamina.

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Implications:

  • The choroidal tumor, initially suspected to be amelanotic melanoma, was definitively diagnosed as schwannoma.
  • Current ancillary diagnostic studies have limited value in definitively differentiating schwannoma from other choroidal tumors.