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Intraabdominal tissue concentration of ertapenem
1University of Ulm, Department of Visceral Surgery, Steinhövelstrasse 9, 89075 Ulm, Germany. mathias.wittau@web.de
The Journal of Antimicrobial Chemotherapy
|January 7, 2006
Summary
Ertapenem concentrations in intraabdominal tissues were measured in 48 patients. Results show significant organ-specific differences, supporting ertapenem
Area of Science:
- Pharmacology
- Infectious Diseases
- Surgical Oncology
Background:
- Ertapenem is approved for intraabdominal infections.
- In vivo ertapenem tissue concentrations are not well-established.
Purpose of the Study:
- To determine ertapenem concentrations in intraabdominal tissues.
- To assess organ-specific differences in ertapenem tissue penetration.
Main Methods:
- 48 patients undergoing intraabdominal surgery received 1g ertapenem intravenously.
- Tissue and plasma samples were collected for drug concentration analysis.
- Liquid chromatography/mass spectrometry and ANCOVA were used for analysis.
Main Results:
- Mean ertapenem tissue concentrations varied by organ: gall bladder (16.0 mg/kg), colon (12.1 mg/kg), small bowel (7.0 mg/kg), liver (4.5 mg/kg), pancreas (3.4 mg/kg).
- Tissue/plasma ratios ranged from 0.088 (liver) to 0.19 (colon).
- Statistically significant organ-specific differences in concentration and penetration were observed.
Conclusions:
- Ertapenem tissue concentrations and penetration vary significantly across intraabdominal organs.
- These pharmacokinetic findings support ertapenem's efficacy for intraabdominal infections.
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