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[New horizons of ED-71 (vitamin D analog)]
1Department of Geriatric Medicine, Graduate School of Medicin, The University of Tokyo.
Abstract:
ED-71 is a vitamin D analog which was designed to have prominent effect on bone tissue. ED-71 has a hydroxypropoxy residue at the 2beta position and binds to the vitamin D receptor with one eighth affinity compared with original 1alpha,25-dihydroxyvitamin D(3). ED-71 has a longer half life than 1alpha,25-dihydroxyvitamin D(3) due to twice as high affinity with vitamin D binding protein in plasma. The result of late phase II study revealed ED-71 increased bone mass in a dose-dependent manner even under sufficient vitamin D supplementation, which accelerates the clinical use of ED-71.
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