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Updated: Jul 18, 2026
Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Published on: July 22, 2020
A PANorama of PAX genes in cancer and development
Ewan J D Robson1, Shu-Jie He, Michael R Eccles
1Department of Pathology, University of Otago, PO Box 913, Dunedin 9001, New Zealand.
Abstract:
Populations of self-renewing cells that arise during normal embryonic development harbour the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour generation. So, control mechanisms are essential to prevent rapidly expanding populations from malignant growth. Transcription factors have crucial roles in ensuring establishment of such regulation, with the Pax gene family prominent amongst these. This review examines the role of Pax family members during embryogenesis, and their contribution to tumorigenesis when subverted.
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