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Updated: Aug 7, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
[Severe refractory pulmonary hypertension after liver transplantation for hepatitis C liver cirrhosis]
C G Dietrich1, C Gartung, E Siewert
1Medizinische Klinik III, Klinikum der RWTH Aachen.
Background:
We report the case of a 43-year-old male with liver cirrhosis based on a chronically active hepatitis C.
Case Report:
Before liver transplantation right-ventricular pressure values of 36 mmHg (+ central venous pressure) were measured whereas, after transplantation, he developed severe pulmonary hypertension with pressure values up to 90 mmHg. These elevated pressure values correlated inversely with graft function. Given the diagnosis of portopulmonary hypertension, we initiated treatment with intravenous epoprostenol and inhalative iloprost but both treatments were not tolerated because of systemic side effects. A combined heart-lung transplantation was considered but the patient died from insufficient cardiac function.
Conclusions:
The case report discusses the present diagnostic and therapeutic state of the art in portopulmonary hypertension and reveals basic problems of the present screening strategy.
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