Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reversible ventricular dysfunction takotsubo cardiomyopathy.

Yoshihiro J Akashi1, Haruki Musha, Keisuke Kida

  • 1Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki-city, Kanagawa-prefecture, Japan.

European Journal of Heart Failure
|January 7, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intradialytic Renal Rehabilitation and Mortality: Results from the Registry of Active Renal Rehabilitation in Dialysis Patients (REVEAL-D).

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Age-Stratified Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure.

JACC. Advances·2026
Same author

Randomized Trial of Finerenone on Urinary Albumin-to-Creatinine Ratio in Type 2 Diabetes Mellitus and CKD.

Kidney international reports·2026
Same author

Relevant Adverse Events and Drug Discontinuation of Sacubitril/Valsartan in Patients with Transthyretin Amyloid Cardiomyopathy - Insights from the REVIEW-HF Registry.

International heart journal·2026
Same author

Prognostic Value of In-Hospital Nutritional Status Improvement in Heart Failure: Insights From JROADHF-NEXT Registry.

Global heart·2026
Same author

The impact of country income level on the management of heart failure with preserved ejection fraction: an international survey.

ESC heart failure·2026

Takotsubo cardiomyopathy, a reversible heart failure, presents with a unique ventricular shape and high norepinephrine levels. This condition generally has a good prognosis and does not recur.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Heart Failure Research

Background:

  • Recognized rapidly reversible heart failure of unknown origin.
  • Characterized by takotsubo-shaped, dyskinetic left ventricle on left ventriculography.

Purpose of the Study:

  • To determine the detailed clinical features of takotsubo cardiomyopathy.

Main Methods:

  • Prospective enrollment of 13 elderly patients (11 women, 2 men; mean age 75.3 years).
  • Patients had normal coronary arteries and takotsubo-like left ventricular dysfunction.

Main Results:

  • Normal coronary arteries confirmed by angiography; takotsubo-shaped ventricle on left ventriculography (apical akinesis, basal hyperkinesis).
  • Significantly elevated plasma norepinephrine levels on admission (0.98 microg/l).

Related Experiment Videos

  • Left ventricular function normalized in 12 patients within a mean of 16.9 hospital days; no recurrence during follow-up.

    • Conclusions:

    • Takotsubo cardiomyopathy is a distinct type of acute heart failure with a generally good prognosis.
    • Potential causes include catecholamine overload, adrenoceptor hypersensitivity, and stress-induced catecholamine dynamic changes.
    • The condition is characterized by rapid reversibility and low recurrence rates.