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Antihypertensive effect of manidipine
Alex Roca-Cusachs1, Filippos Triposkiadis
1Internal Medicine Department, Hospital Santa Creu i Sant Pau, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. aroca@hsp.santpau.es
Drugs
|January 10, 2006
Summary
Manidipine effectively lowers blood pressure in patients with mild-to-moderate hypertension. This dihydropyridine calcium channel antagonist offers long-term control with good tolerability, making it a suitable first-line treatment option.
Area of Science:
- Cardiovascular Pharmacology
- Hypertension Management
Background:
- Manidipine is a third-generation, vasoselective dihydropyridine (DHP) calcium channel antagonist.
- Essential hypertension management requires effective and well-tolerated antihypertensive agents.
Purpose of the Study:
- To evaluate the efficacy and tolerability of manidipine for blood pressure reduction.
- To assess manidipine's suitability as a first-line treatment for hypertension.
Main Methods:
- Once-daily administration of manidipine.
- Assessment of blood pressure (BP) reduction over a 24-hour dosing period.
- Evaluation of long-term efficacy and tolerability, including effects on glucose and lipid metabolism.
Main Results:
- Manidipine effectively reduces blood pressure in patients with mild-to-moderate essential hypertension.
- The drug demonstrates a gradual onset and long duration of action, maintaining reduced BP levels throughout the dosing period.
- Manidipine shows comparable BP-lowering capacity to other DHPs and angiotensin-converting enzyme inhibitors, with neutral effects on glucose and lipid metabolism.
Conclusions:
- Manidipine is effective for long-term blood pressure control in mild-to-moderate hypertension.
- It is well-tolerated, with no evidence of intolerance and neutral metabolic effects.
- Manidipine is a viable first-line option for managing hypertension, including in diabetic and elderly patients.
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