Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple endocrine neoplasia: paediatric perspective.

A Rodriguez-Sánchez1, C López-Menchero, M D Rodríguez-Arnao

  • 1Unidad de Metabolismo y Desarrollo, Departamento de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain. amparorodriguezsanchez@yahoo.es

Journal of Pediatric Endocrinology & Metabolism : JPEM
|January 10, 2006
PubMed
Summary

Neuroendocrine tumors are diverse cancers originating from common cells. Improved screening and early treatment strategies, particularly for Multiple Endocrine Neoplasia (MEN) syndromes, have significantly reduced cancer morbidity and mortality.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How do meteorological conditions impact the effectiveness of various traffic measures on NO<sub>x</sub> concentrations in a real hot-spot?

The Science of the total environment·2024
Same author

Effect of salinity variation on the autotrophic kinetics of the start-up of a membrane bioreactor and hybrid moving bed biofilm reactor-membrane bioreactor at low hydraulic retention time.

Water science and technology : a journal of the International Association on Water Pollution Research·2018
Same author

Isolation and metagenomic characterization of bacteria associated with calcium carbonate and struvite precipitation in a pure moving bed biofilm reactor-membrane bioreactor.

Biofouling·2015
Same author

Effect of ciprofloxacin antibiotic on the partial-nitritation process and bacterial community structure of a submerged biofilter.

The Science of the total environment·2014
Same author

Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome.

The pharmacogenomics journal·2013
Same author

Kinetic analysis and mathematical modeling of growth and lactic acid production of Lactobacillus casei var. rhamnosus in milk whey.

Journal of dairy science·2010

Area of Science:

  • Oncology
  • Genetics
  • Endocrinology

Background:

  • Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms arising from a common precursor cell population.
  • These tumors can affect various endocrine glands and dispersed cells, occurring sporadically or as inherited familial syndromes like Multiple Endocrine Neoplasia (MEN).
  • MEN syndromes are autosomal dominant cancer syndromes with 100% penetrance, categorized into MEN type 1 and type 2.

Purpose of the Study:

  • To highlight the significant impact of improved screening and early treatment strategies on reducing morbidity and mortality in patients with MEN.
  • To emphasize the particular relevance of MEN 2 and medullary thyroid carcinoma (MTC) in childhood, necessitating urgent diagnosis and treatment.
  • To underscore how understanding the genetic basis of MTC has revolutionized the management of its familial forms.

Related Experiment Videos

Main Methods:

  • Review of existing literature on neuroendocrine tumors and MEN syndromes.
  • Analysis of the impact of screening and early treatment protocols on patient outcomes.
  • Discussion of the genetic underpinnings of familial MTC and its clinical implications.

Main Results:

  • Improved screening and early treatment strategies have led to a favorable impact on morbidity and mortality associated with malignant tumors in MEN.
  • Early diagnosis and treatment are crucial for MEN 2 and medullary thyroid carcinoma (MTC), especially in pediatric cases.
  • The elucidation of the genetic basis for MTC has transformed the management approach for hereditary MTC.

Conclusions:

  • Advances in screening and early intervention have markedly improved outcomes for patients with MEN-associated cancers.
  • Prompt diagnosis and management are critical for pediatric cases of MEN 2 and MTC.
  • Genetic insights into MTC have revolutionized the care of individuals with familial forms of this cancer.