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Related Experiment Videos

Atypical extraventricular neurocytoma.

Sayaka Moriguchi1, Atsushi Yamashita, Kousuke Marutsuka

  • 1Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Pathology International
|January 10, 2006
PubMed
Summary

Extraventricular neurocytoma (EVN) is a rare brain tumor. This case highlights key diagnostic features of atypical EVN, aiding in differentiating it from other parenchymal brain tumors like oligodendroglioma.

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Area of Science:

  • Neuropathology
  • Neuro-oncology
  • Rare Brain Tumors

Background:

  • Extraventricular neurocytoma (EVN) is a rare neuroblastic tumor with potential for diagnostic challenges.
  • Accurate diagnosis is crucial for appropriate patient management and prognosis.

Observation:

  • A case of atypical EVN in a 54-year-old woman presented as a right parietal lobe lesion.
  • Histological examination revealed monotonous tumor cells with perinuclear clearing, vascular proliferation, and high mitotic activity.
  • Immunohistochemistry showed strong synaptophysin positivity and negative staining for GFAP and Olig2.

Findings:

  • The tumor exhibited a delicate fibrillary matrix resembling neuropil.
  • A Ki-67 labeling index of 13.0% indicated high proliferative activity.

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  • Absence of p53 accumulation suggests alternative oncogenic pathways in atypical EVN.

    • Implications:

    • EVN should be considered in the differential diagnosis of parenchymal brain tumors, particularly oligodendroglioma.
    • Key diagnostic markers include the neuropil-like matrix, synaptophysin positivity, and Olig2 negativity.
    • Further research into the oncogenesis of atypical EVN is warranted, given the high proliferation without p53 accumulation.