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Hypertension, coronary artery disease and insulin resistance--linked disorders with an impact on treatment

C M Florkowski1, J Harrison, M J Kendall

  • 1Queen Elizabeth Hospital, Birmingham, U.K.

Journal of Clinical Pharmacy and Therapeutics
|June 1, 1992
PubMed

Insights

Hypertension increases coronary artery disease risk, partly via hyperinsulinemia. Some blood pressure drugs worsen this, potentially increasing heart risks.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Hypertension is a major risk factor for coronary artery disease (CAD).
  • Antihypertensive therapies have not consistently reduced CAD event incidence.
  • Hypertension is linked to hyperinsulinemia, obesity, and type 2 diabetes.

Purpose of the Study:

  • To explore the relationship between hypertension and hyperinsulinemia.
  • To explain how elevated plasma insulin accelerates CAD.
  • To inform antihypertensive drug selection based on these links.

Main Methods:

  • Review of existing literature on hypertension, hyperinsulinemia, and CAD.
  • Analysis of mechanisms linking increased insulin levels to cardiovascular risk.
  • Evaluation of the impact of antihypertensive drugs on insulin levels.

Main Results:

  • Hypertension is associated with hyperinsulinemia, a state of high insulin levels.
  • Certain antihypertensive drugs, like thiazide diuretics, can exacerbate hyperinsulinemia.
  • Elevated insulin levels may contribute to the accelerated development of CAD.

Conclusions:

  • The link between hypertension and hyperinsulinemia is a critical factor in CAD development.
  • Drug selection for hypertension should consider potential effects on insulin levels.
  • Understanding these mechanisms may lead to improved prevention and treatment strategies for CAD in hypertensive patients.

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