Related Experiment Video
Updated: Aug 13, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
[Peripheral neuropathy and deterioration of the cognitive functions associated to chronic exposure to
Irene Orozco-De Los Ríos1, Pedro Miguel Sánchez-Vizcaíno, Diego González-Ramírez
1Hospital General de Zona con Medicina Familliar 2, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León. guerairene@yahoo.es
Objective:
To analyze the relationship between the chronic exposure (EC) to organophosphated insecticides (IOF) with the presence of peripheral neuropathy (NP) and the deterioration of cognitive functions (DFC).
Design Of The Study:
Cross-section, comparative and observational.
Material And Methods:
Workers with more than three months of seniority, who participated in any stage of the process of production of IOF were included, and those with alterations in the neurological function were excluded. Two control groups were made up: the first one, without direct exposure to IOF, and the second one, without any exposure whatsoever to IOF. A physical examination was practiced on inferior limbs and a motor neuroconduction of the fibular nerves was carried out. The Minimum Exam of the Mental State was set (Mental Mini). The sampling was not random.
Results:
It was found that the presence of DFC and the clinical data for NP were greater in the exposed group than in the controls, (p < 0.05). Besides, data with a tendency to the continuation in the parameters of latencies, widths and waves F for the motor neuroconduction of inferior limbs were presented.
Conclusions:
The long term exposure to IOF is related to deterioration in the cognitive function; as well as to the neurological manifestations in inferior limbs that condition an injury in the peripheral nerve, without being conclusive about the loss of its function.
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Diabetic Neuropathy
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Hepatic Encephalopathy
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Alzheimer Disease l: Introduction