Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mosquito glutathione transferases.

Hilary Ranson1, Janet Hemingway

  • 1Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Methods in Enzymology
|January 10, 2006
PubMed
Summary

Glutathione transferases (GSTs) are crucial enzymes in mosquitoes, involved in detoxifying insecticides and maintaining cellular redox balance. This review explores their diverse functions and roles in insecticide resistance and vectorial capacity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-omics analysis identifies loci associated with pyrethroid resistance across sister species in the Anopheles gambiae species complex.

BMC genomics·2026
Same author

The genomics of insecticide resistance in Anopheles funestus: insights from a large bed-net trial.

BMC genomics·2026
Same author

Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control.

Molecular ecology·2026
Same author

Differential effects of dual and synergist-based insecticide-treated bed nets on pyrethroid resistance and L995F/S knockdown resistance mutation dynamics in Anopheles gambiae s.l. populations in south-western Burkina Faso.

Parasites & vectors·2025
Same author

Three-year trends in malaria transmission parameters under deployment of Interceptor®G1, Interceptor®G2 and PermaNet®3.0 insecticide-treated bed nets in South-Western Burkina Faso.

Malaria journal·2025
Same author

Correction: Overcoming barriers to NHS adoption of innovative IPC products: A qualitative study of SMEs in the Liverpool city region.

PloS one·2025

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Entomology

Background:

  • Glutathione transferases (GSTs) are a diverse enzyme family catalyzing the conjugation of glutathione to electrophilic substrates.
  • In mosquitoes, GSTs are primarily studied for their role in insecticide metabolism and resistance.
  • Emerging research highlights their importance in maintaining cellular redox status and vectorial capacity.

Purpose of the Study:

  • To review the diversity and functional roles of glutathione transferases (GSTs) in mosquitoes.
  • To discuss the involvement of mosquito GSTs in insecticide metabolism and resistance.
  • To explore the contribution of GSTs to mosquito redox homeostasis and vectorial capacity.

Main Methods:

  • Literature review of existing studies on mosquito glutathione transferases.
  • Analysis of GST gene families and protein structures in insects.
  • Synthesis of information on GST substrate specificity and enzymatic activity.

Main Results:

  • Mosquitoes possess over 30 glutathione transferase genes, with further diversity from alternative splicing.
  • GSTs play a significant role in metabolizing a wide range of insecticides, contributing to resistance.
  • These enzymes are also implicated in endogenous detoxification pathways and maintaining cellular redox balance.

Conclusions:

  • Glutathione transferases are multifunctional enzymes critical for mosquito survival and adaptation.
  • Understanding mosquito GSTs is vital for developing effective insecticide resistance management strategies.
  • Further research into GSTs' roles in redox homeostasis may offer new targets for controlling disease vectors.

Related Experiment Videos