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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers
Tomonori Habuchi1, Michael Marberger, Michael J Droller
1Department of Urology, Kyoto University, Kyoto, Japan.
Urology
|January 10, 2006
Summary
Certain bladder cancer markers show promise for predicting recurrence and progression, but data remain inconsistent. Standardization and clear criteria are needed for reliable clinical use.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Bladder cancer prognosis relies on predicting tumor recurrence, progression, metastasis, and treatment response.
- Existing prognostic indicators require further validation for clinical application.
Framework:
- The International Consensus Panel reviewed PubMed articles on bladder cancer prognostic indicators.
- Indicators were categorized into six groups: microsatellite-associated markers, oncogenes, tumor suppressor genes, cell cycle regulators, angiogenesis factors, and extracellular matrix adhesion molecules.
Implementation:
- The panel evaluated the predictive ability of various markers based on retrospective studies.
- Markers like Ki-67 and p53 show potential for predicting bladder cancer recurrence and progression.
Implications:
- Heterogeneous data necessitate standardization of marker evaluation techniques and clear endpoint definitions.
- Development of accurate, independent prognostic indicators is crucial for effective clinical management of bladder cancer patients.
