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Related Experiment Videos

Fas pulls the trigger on psoriasis.

Amos Gilhar1, Ron Yaniv, Bedia Assy

  • 1Laboratory for Skin Research, Rappaport Building, Technion Faculty of Medicine, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel. fligilhar@matat.health.gov.il

The American Journal of Pathology
|January 10, 2006
PubMed
Summary
This summary is machine-generated.

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Fas/FasL signaling drives psoriasis by inducing inflammatory cytokines like TNF-alpha. Blocking this pathway with antibodies prevents psoriasis development and reduces epidermal inflammation.

Area of Science:

  • Immunodermatology
  • Molecular Biology
  • Cell Signaling

Background:

  • Fas/FasL signaling traditionally induces apoptosis but can also trigger inflammatory cytokines, including tumor necrosis factor (TNF)-alpha.
  • This inflammatory pathway is active in cells with high Bcl-xL, a feature of psoriatic epidermis which has low apoptosis.
  • TNF-alpha is a key factor in psoriasis pathogenesis.

Purpose of the Study:

  • To investigate the hypothesis that inflammatory Fas signaling, mediated by activated lymphocytes, induces psoriasis.
  • To explore the role of Fas/FasL signaling in the early induction of psoriasis.

Main Methods:

  • Grafting noninvolved skin from psoriasis patients onto immunodeficient mice.
  • Inducing psoriasis via injection of activated, FasL-positive autologous natural killer (NK) cells.

Related Experiment Videos

  • Administering blocking anti-Fas (ZB4) or anti-FasL (4A5) antibodies to assess inhibition of psoriasis induction.

    • Main Results:

    • Psoriasis induction was significantly inhibited by anti-Fas and anti-FasL antibodies.
    • Anti-Fas antibody treatment reduced epidermal cell proliferation (Ki-67), epidermal thickness, and expression of TNF-alpha, IL-15, HLA-DR, and ICAM-1.
    • Fas/FasL signaling is essential for inducing key inflammatory cytokines like TNF-alpha and IL-15 in this psoriasis model.

    Conclusions:

    • Fas/FasL signaling is a critical early event in lymphocyte-induced psoriasis.
    • This pathway is necessary for the induction of crucial inflammatory cytokines that drive psoriasis.
    • Targeting Fas/FasL signaling offers a potential therapeutic strategy for psoriasis.