Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered subicular MAP2 immunoreactivity in schizophrenia.

Gorazd Rosoklija1, John G Keilp, Glen Toomayan

  • 1Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA. gbr2@columbia.edu

Prilozi
|January 10, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome.

bioRxiv : the preprint server for biology·2026
Same author

Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia.

Nature communications·2026
Same author

Author Correction: A human brain map of mitochondrial respiratory capacity and diversity.

Nature·2025
Same author

A rare variant in <i>GPR156</i> associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A human brain map of mitochondrial respiratory capacity and diversity.

Nature·2025
Same author

Gender differences in the relationship between the triglyceride-glucose index and serum Klotho concentrations among the middle-aged and elderly: a cross-sectional analysis.

BMC endocrine disorders·2024

Reduced microtubule-associated protein 2 (MAP2) in the subiculum was observed in some schizophrenia patients, correlating with fewer symptoms. This MAP2 loss may be an adaptive response in schizophrenia, unlike in dementia where it indicates neuronal damage.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cell Biology

Background:

  • Microtubule-associated protein 2 (MAP2) is crucial for neuronal structure and function.
  • Previous studies suggested reduced MAP2 in the subiculum of schizophrenia patients.

Purpose of the Study:

  • To independently verify the loss of subicular MAP2 in schizophrenia.
  • To investigate clinical associations with subicular MAP2 loss in psychiatric disorders.

Main Methods:

  • Immunohistochemistry for MAP2 in the hippocampus of 94 psychiatric patients and 17 controls.
  • Evaluation of lifelong symptomatology using the modified Diagnostic Evaluation After Death.

Main Results:

  • Subicular MAP2 immunoreactivity was reduced in 20% of schizophrenia, 8% of mood disorder, and 22% of dementia cases, but not in controls.

Related Experiment Videos

  • In schizophrenia, MAP2 loss correlated with fewer positive and negative symptoms.
  • In dementia, MAP2 loss was associated with subicular gliosis; this was not observed in schizophrenia.

    • Conclusions:

    • Reduced subicular MAP2 is present in a subset of schizophrenia patients and may represent an adaptive response.
    • MAP2 loss in schizophrenia differs from dementia, where it is linked to neuronal damage (gliosis).
    • Further research is needed to determine the underlying causes of decreased MAP2 in schizophrenia.