Related Experiment Video
Updated: Aug 13, 2026

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
Published on: November 17, 2015
[Effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparticles]
Jun He1, Shi-xiang Hou, Jian-fang Feng
1Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China.
Objective:
To investigate effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparuicles.
Method:
Solid lipid nanoparticles (SLN) of various sizes (150 nm, 500 nm and 1000 nm) using Compritol 888 ATO as the material and silymarin (SM) as a model drug were prepared. Silybinin concentration in plasma of rats were determined by RP-HPLC with UV detector. The main pharmacokinetic parameters were calculated by 3p97.
Result:
Results showed that the AUC of 150 nm SLN was 2.08 fold that of 500 nm SLN and 2.54 fold of 1000 nm SLN treated orally to rats (P < 0.05). The oral bioavailability of 150 nm SLN was remarkably higher than the other two size SLN.
Conclusion:
This has important implications in designing of SM-SLN as a new oral drug delivery system.
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Bioavailability Enhancement: Drug Solubility Enhancement
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Bioavailability Enhancement: Drug Permeability Enhancement
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Influencing Drug Absorption: Physicochemical Parameters
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...

