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Related Experiment Videos

Open-label risperidone for Asperger's disorder: negative symptom spectrum response.

Jeffrey L Rausch1, Elizabeth L Sirota, Donna L Londino

  • 1Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augustam GA 30912, USA. jeffreyr@mail.mcg.edu

The Journal of Clinical Psychiatry
|January 13, 2006
PubMed
Summary

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Risperidone treatment significantly improved negative symptoms in adolescent males with Asperger's disorder. Further placebo-controlled trials are recommended to confirm these promising findings for Asperger's symptoms.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Asperger's disorder shares negative symptoms with schizophrenia and other disorders.
  • Risperidone is an effective treatment for negative symptoms in schizophrenia.

Purpose of the Study:

  • To investigate the efficacy of risperidone in treating negative symptoms of Asperger's disorder.
  • To assess risperidone's impact on various psychiatric rating scales in patients with Asperger's disorder.

Main Methods:

  • A 12-week, open-label pilot study involving 13 male patients (aged 6-18) diagnosed with Asperger's disorder.
  • Patients received risperidone, with dosage adjusted based on clinical need and tolerability.
  • Primary outcome was measured by the Scale for the Assessment of Negative Symptoms (SANS); secondary outcomes included other psychiatric scales.

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Main Results:

  • Statistically significant improvement in SANS scores from baseline for both 12-week completers and LOCF analyses (p < .0001).
  • Significant improvements observed across all secondary efficacy measures in both completer and LOCF analyses (p < .005).

Conclusions:

  • Risperidone treatment led to significant symptom improvement in patients with Asperger's disorder.
  • The positive results from this small pilot study warrant further investigation with placebo-controlled trials.