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Modification of the computational procedure in Parker and Bregman's method of calculating sample size from matched
Ilya Novikov1, Bernice Oberman, Laurence Freedman
1Biostatistics Unit, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel. IliaN@gertner.health.gov.il
Abstract:
Several authors have addressed the problem of calculating sample size for a matched case-control study with a dichotomous exposure. The approach of Parker and Bregman (1986, Biometrics42, 919-926) is, in our view, one of the most satisfactory, since it requires specification of quantities that are often easily available to the investigator. However, its recommended implementation involves a computational approximation. We show here that the approximation performs poorly in extreme situations and can be easily replaced with a more exact calculation.
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