Related Experiment Video

Updated: Aug 13, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Adding pharmacogenomics to the development of new marine-derived anticancer agents

José Jimeno1, Miguel Aracil, Juan Carlos Tercero

  • 1PharmaMar R & D, Colmenar Viejo, Madrid, Spain. jjimeno@pharmamar.com

Journal of Translational Medicine
|January 13, 2006
PubMed

Insights

Marine compounds show promise for treating resistant cancers. Pharmacogenomic tools aid in developing targeted therapies from marine sources for future customized cancer treatment.

Area of Science:

  • Marine natural products
  • Drug discovery
  • Pharmacogenomics

Background:

  • Nature is a vital source for anticancer drug development.
  • Marine ecosystems offer novel compounds for treating drug-resistant cancers.
  • Combination therapies with marine-derived agents are being explored for chronic cancer treatment.

Purpose of the Study:

  • To review the development of marine-derived anticancer agents.
  • To highlight the integration of pharmacogenomic tools in drug development.
  • To identify new cellular targets for cancer therapy.

Main Methods:

  • Review of marine-derived compounds (Yondelis, Aplidin, Kahalalide F).
  • Integration of pharmacogenomic tools.
  • Assessment of activity in resistant solid tumors.

Main Results:

  • Three marine-derived compounds are in Phase II or III clinical trials.
  • Pharmacogenomic tools enhance the targeted selectivity of these agents.
  • Development of novel agents for resistant solid tumors.

Conclusions:

  • Marine natural products are a promising source for novel anticancer drugs.
  • Pharmacogenomic approaches are crucial for developing targeted cancer therapies.
  • Marine-derived compounds may lead to customized cancer treatments in the future.

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