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Published on: March 30, 2017
Development of cyclodextrin microspheres for pulmonary drug delivery
Malika Skiba1, Frédéric Bounoure, Cecile Barbot
1Laboratoire de Pharmacie Galénique et Biopharmacie, ADEN-UPRES EA 3234, UFR de Medecine-Pharmacie, Rouen Cedex, France.
Summary
Beta-cyclodextrin microparticles under 5 micrometers were created for pulmonary drug delivery. Amikacin sulfate was successfully encapsulated within these beta-cyclodextrin particles for alveolar administration.
Area of Science:
- * Pharmaceutical Sciences
- * Materials Science
- * Nanotechnology
Background:
- * Developing stable drug delivery vectors for pulmonary administration is crucial for effective treatment of respiratory diseases.
- * Beta-cyclodextrins (beta-CD) offer potential as biocompatible carriers due to their unique structure and properties.
- * Microparticle-based drug delivery systems can enhance drug targeting and controlled release in the lungs.
Purpose of the Study:
- * To synthesize stable beta-cyclodextrin (beta-CD) microparticles with diameters less than 5 micrometers.
- * To optimize the synthesis process for creating microparticles suitable for alveolar drug delivery.
- * To investigate the encapsulation of amikacin sulfate within the synthesized beta-CD microparticles.
Main Methods:
- * Interfacial cross-linking of beta-cyclodextrins with terephthaloyl chloride in NaOH.
- * Optimization of synthesis parameters including monomer concentration, NaOH concentration, reaction time, agitation rate, and surfactant presence.
- * Characterization of microparticles using laser diffraction, pH measurements, IR spectroscopy, and Differential Scanning Calorimetry.
- * Evaluation of amikacin sulfate encapsulation efficiency and yield at different preparation stages.
Main Results:
- * Optimized synthesis yielded beta-CD microparticles with diameters < 5 micrometers.
- * Key parameters for optimization included 1 M NaOH, 4.5% terephthaloyl chloride, 5% surfactant, 30 min reaction time, and 24000 rpm agitation.
- * Amikacin sulfate encapsulation was most effective during the solubilization step or immediately prior to freeze-drying.
Conclusions:
- * Beta-cyclodextrin microparticles of approximately 5 micrometers in diameter can be effectively produced.
- * The synthesized beta-CD microparticles are suitable for encapsulating amikacin sulfate for pulmonary drug delivery.
- * This approach offers a promising strategy for targeted drug delivery to the alveolar region.
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