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Updated: Aug 13, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
Tandem mass spectrometry in quadrupole ion trap and ion cyclotron resonance mass spectrometers
1Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.
Abstract:
Instruments that trap ions in a magnetic and/or electric field play a very important role in the analysis of biomolecules. The two predominant instruments in the category of trapping instrument are the quadrupole ion trap mass spectrometer (QIT-MS) and the ion cyclotron resonance (ICR) MS. The latter is also commonly called Fourier transform MS (FT-MS). The QIT is an inexpensive, simple, and rugged MS used for various routine applications. The ICR-MS is an expensive, high-performance instrument with figures of merit for resolution and mass accuracy surpassing all other mass spectrometers. This chapter covers the basic principles of operation of these instruments, including the trapping/manipulation/detection of ions and various approaches used to activate ions to perform tandem mass spectrometry experiments.
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