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The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
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The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

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delta-Lactone from Oedogonium capillare and their effects on rat ileum

Rosa Martha Perez Gutierrez1, Solis Rosario Vargas, Francisco Martinez Martinez

  • 1Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industias extractivas IPN, Punto fijo 16, col. Torres Lindavista cp 07708, México D.F., México. rmpg@prodigy.net.mx

Natural Product Research
|January 13, 2006
PubMed

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In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...