Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine: the rewarding years.

Charles A Marsden1

  • 1School of Biomedical Sciences, Institute of Neuroscience, Medical School, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH. Charles.marsden@nottingham.ac.uk

British Journal of Pharmacology
|January 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anxiety-like behaviour and c-fos expression in rats that inhaled vetiver essential oil.

Natural product research·2015
Same author

Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2013
Same author

How do we re-engage the pharmaceutical industry in research on serotonin and psychiatric disorders?

ACS chemical neuroscience·2013
Same author

Sensory gating, cannabinoids and schizophrenia.

Neuropharmacology·2012
Same author

The effects of chronic administration of tranylcypromine and rimonabant on behaviour and protein expression in brain regions of the rat.

Pharmacology, biochemistry, and behavior·2011
Same author

Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2011
Same journal

Glucagon-like peptide-1 improves vascular endothelial dysfunction in hypertensive mice via CREB-driven transcriptional regulation of long non-coding RNA 155383.

British journal of pharmacology·2026
Same journal

The chemokine receptor-like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling.

British journal of pharmacology·2026
Same journal

Peripheral targets for neuropathic pain.

British journal of pharmacology·2026
Same journal

Therapeutic potential of liver X receptor agonist GW3965 in preserving myelin integrity following traumatic brain injury.

British journal of pharmacology·2026
Same journal

The role of protein arginine methyltransferases in sickle cell-mediated neurovascular impairments in mice.

British journal of pharmacology·2026
Same journal

β-Cyclodextrin inclusion enhances the pro-resolving effects of the annexin A1 mimetic Ac2-26 in a mouse model of antigen-induced arthritis.

British journal of pharmacology·2026
See all related articles

Dopamine is a key neurotransmitter influencing movement, reward, and cognition. Future research should focus on how dopamine integrates information for normal behavior and disease states like Parkinson's and schizophrenia.

Area of Science:

  • Neuroscience
  • Neuropharmacology
  • Psychiatry

Background:

  • Dopamine's role has evolved from a metabolic intermediate to a critical neurotransmitter.
  • It is implicated in movement control, Parkinson's disease, schizophrenia, and ADHD.
  • Dopamine is central to the brain's reward system and drug addiction.

Observation:

  • Extensive knowledge exists on dopamine metabolism and receptor systems.
  • The precise functions of dopamine receptors and pathways in behavior are less understood.
  • Mechanisms underlying dopamine system dysfunction in Parkinson's disease and schizophrenia remain unclear.

Findings:

  • Dopamine neurons, though few, profoundly impact brain function.
  • Current understanding of dopamine's role in integrating information for behavior is limited.

Related Experiment Videos

  • The specific reasons for dopamine system degeneration in neurodegenerative and neurodevelopmental disorders are not well-elucidated.

    • Implications:

    • Future research must explore dopamine's role in information integration for behavior.
    • An integrated approach is needed to understand dopamine's complex functions.
    • This approach promises improved treatments for dopamine-related disorders.