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Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
Cannabinoid pharmacology: the first 66 years
1School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD. rgp@abdn.ac.uk
British Journal of Pharmacology
|January 13, 2006
Summary
Research into cannabinoid pharmacology since the 1940s led to discovering cannabinoid receptors and endogenous ligands. This understanding highlights the endogenous cannabinoid system's role in health and disease, paving the way for new therapeutics.
Area of Science:
- Pharmacology
- Neuroscience
- Biochemistry
Background:
- Cannabinoid research initiated in the 1940s, following the initial detection of cannabinoids in cannabis.
- Early research focused on understanding the chemical constituents of cannabis and their biological effects.
Observation:
- Pharmacological studies led to the identification of cannabinoid receptors, specifically CB1 and CB2.
- Endogenous ligands for these receptors were subsequently discovered, revealing an internal signaling system.
Findings:
- The development of selective agonists and antagonists for CB1 and CB2 receptors.
- Established the significant roles of the endogenous cannabinoid system in maintaining physiological balance and in disease processes.
Implications:
- Drugs modulating the endogenous cannabinoid system hold significant therapeutic potential.
- Future research directions include further exploration of therapeutic applications and system modulation.
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