Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuromuscular block.

W C Bowman1

  • 1Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G4 0NR. billbowman@btinternet.com

British Journal of Pharmacology
|January 13, 2006
PubMed
Summary
This summary is machine-generated.

Neuromuscular blocking drugs, derived from curare, revolutionized surgical anesthesia. Modern agents offer improved safety and targeted actions, with new antagonists promising rapid reversal.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vitro activation and repression of photosynthesis gene transcription in Rhodobacter capsulatus.

Molecular microbiology·1999
Same author

A bacterial ATP-dependent, enhancer binding protein that activates the housekeeping RNA polymerase.

Genes & development·1998
Same author

Translational activation by an NtrC enhancer-binding protein.

Journal of molecular biology·1998
Same author

Characterization of the Rhodobacter capsulatus housekeeping RNA polymerase. In vitro transcription of photosynthesis and other genes.

The Journal of biological chemistry·1997
Same author

Reminiscent meanderings through most of a mainly pharmacological life.

Pharmacology & toxicology·1997
Same author

Actions of triethylcholine on neuromuscular transmission. 1961.

British journal of pharmacology·1997
Same journal

Glucagon-like peptide-1 improves vascular endothelial dysfunction in hypertensive mice via CREB-driven transcriptional regulation of long non-coding RNA 155383.

British journal of pharmacology·2026
Same journal

The chemokine receptor-like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling.

British journal of pharmacology·2026
Same journal

Peripheral targets for neuropathic pain.

British journal of pharmacology·2026
Same journal

Therapeutic potential of liver X receptor agonist GW3965 in preserving myelin integrity following traumatic brain injury.

British journal of pharmacology·2026
Same journal

The role of protein arginine methyltransferases in sickle cell-mediated neurovascular impairments in mice.

British journal of pharmacology·2026
Same journal

β-Cyclodextrin inclusion enhances the pro-resolving effects of the annexin A1 mimetic Ac2-26 in a mouse model of antigen-induced arthritis.

British journal of pharmacology·2026
See all related articles

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Neuroscience

Background:

  • Curare, a South American arrow poison, has a long history of use, with its neuromuscular blocking properties studied since the 19th century.
  • Tubocurarine, a key curare alkaloid, was instrumental in understanding acetylcholine's role in neuromuscular transmission.
  • Neuromuscular blocking drugs became crucial in surgical anesthesia after 1943.

Observation:

  • Depolarizing blocking drugs, like suxamethonium, offer rapid onset and short duration, useful for tracheal intubation.
  • Nondepolarizing blocking drugs act as reversible acetylcholine receptor antagonists.
  • The atracurium group features self-destruction, beneficial in renal or hepatic impairment.
  • The vecuronium group is noted for minimal side effects.

Findings:

Related Experiment Videos

  • Rocuronium, a vecuronium-group drug, provides rapid onset for intubation.
  • A novel cyclodextrin antagonist shows promise for rapidly terminating rocuronium's action by chelating the drug.

Implications:

  • Advancements in neuromuscular blocking agents enhance surgical safety and patient outcomes.
  • The development of specific antagonists like cyclodextrins offers greater control over drug duration.
  • These innovations are particularly valuable for patients with organ dysfunction and in emergency airway management.