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Updated: Aug 13, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal
Y Jamshidi1, H Snieder, X Wang
1Department of Clinical Developmental Sciences, St George's, University of London, London, UK.
Aims/Hypothesis:
Inhibition of signal transduction by suppressor of cytokine signalling-3 (SOCS-3) potentially influences resistance to insulin and leptin. The aim of this study was to test the association between three single-nucleotide polymorphisms (SNPs) representative of common linkage disequilibrium clusters in SOCS3 (rs4969169, rs12953258 and rs8064821) and obesity measures, insulin sensitivity measures and serum lipids in the general population.
Methods:
The three SNPs, which had rare allele frequencies >0.06, were genotyped in 2,777 female twins of European extraction (mean age 47.4+/-12.5 years) from the St Thomas' UK Adult Twin Registry (Twins UK).
Results:
Minor allele frequencies were as follows: rs4969169=0.067, rs12953258=0.097 and rs8064821=0.101. Individual SOCS3 SNPs were not associated with general or central obesity, or with two indices of insulin sensitivity (homeostasis model assessment and insulin sensitivity measure).
Conclusions/Interpretation:
The results do not indicate that any of the three SNPs studied are associated with obesity, insulin measures or lipid measures.
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