Related Experiment Video
Updated: Aug 13, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
A spirocyclic P-S cage cation: synthesis and formation of P7S6I2+
Marcin Gonsior1, Ingo Krossing, Eberhard Matern
1Universität Karlsruhe TH, Institut für Anorganische Chemie, Engesserstrasse Geb. 30.45, 76128 Karlsruhe (Germany).
Abstract:
Upon ionization of the P4S3I2 molecule with Ag[Al(OR)4], a highly reactive sulfonium cation P4S3I+ is generated (NMR simulated and assigned). At -80 degrees C this cation reacts with additional P4S3I2 to give either an iodophosphonium P4S3I3+ cation (NMR simulated and assigned) and P4S3 or to give several isomers of a metastable compound that is probably P8S3I3+. This mixture decomposes at 0 degrees C to give only three isomers of the spirocyclic P7S6I2+ cage cation (31P NMR simulated and assigned, X-ray of one isomer, IR assigned). The oxidation of the [Ag(P4S3)2]+ complex by I2 also resulted in the formation of P7S6I2+, but with more by-products. The spirocyclic 15-atom cage of P7S6I2+ has no precedent and contains the first phosphonium center bonded only to P and S atoms. This structural element gives the first experimental clue as to how formal charge-bearing elements in the still unknown class of binary P-Ch (Ch = chalcogen) or homopolyatomic P cations may be constructed.
Related Concept Videos
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Modifications in the RER
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.
ATP Synthase: Mechanism
Coat Assembly and GTPases
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
Directing Proteins to the Rough Endoplasmic Reticulum

![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)