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Randomized, controlled trial of antibiotic therapy for Escherichia coli O157:H7 enteritis
F Proulx1, J P Turgeon, G Delage
1Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Québec, Canada.
The Journal of Pediatrics
|August 1, 1992
Abstract:
We undertook a prospective, controlled study to evaluate the effect of trimethoprim-sulfamethoxazole in children with proven Escherichia coli O157:H7 enteritis on the duration fo symptoms, on fecal excretion of pathogen, and on the risk of progression to hemolytic-uremic syndrome. There was no statistically significant effect of treatment on progression of symptoms, fecal pathogen excretion, or the incidence of HUS (2/22 vs 4/25; p = 0.67). Our results suggest that a multicentric trial using rapid diagnostic methods to permit early randomization should be carried out.