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Related Experiment Videos

Declarative memory impairment in pediatric bipolar disorder.

David C Glahn1, Carrie E Bearden, Sheila Caetano

  • 1Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. glahn@uthscsa.edu

Bipolar Disorders
|January 13, 2006
PubMed
Summary
This summary is machine-generated.

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Children with bipolar I disorder (BP-I) show verbal declarative memory deficits, similar to adults. These memory impairments in juvenile BP-I may be a trait marker, not linked to mood symptoms.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Child and Adolescent Mental Health

Background:

  • Verbal declarative memory impairment is a known trait marker in adult bipolar disorder.
  • Such impairments have not been well-documented in juvenile-onset bipolar disorder.
  • This study investigates declarative memory in children with bipolar disorder.

Purpose of the Study:

  • To assess verbal declarative memory in a large sample of children with bipolar disorder.
  • To compare memory performance across different subtypes of juvenile bipolar disorder (BP-I, BP-II, BP-NOS) and healthy controls.
  • To determine if memory impairments are trait-related or secondary to clinical state.

Main Methods:

  • Forty-one children and adolescents diagnosed with bipolar disorder (BP-I, BP-II, BP-NOS) participated.

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  • Seventeen demographically matched healthy children served as controls.
  • A standardized learning and memory test was administered to all participants.

    • Main Results:

    • Children with bipolar I disorder (BP-I) demonstrated significantly lower word recall and recognition compared to healthy controls.
    • Children with bipolar II disorder (BP-II) and bipolar disorder not otherwise specified (BP-NOS) did not show significant memory differences from controls.
    • Individuals with BP-NOS exhibited more perseverative errors and intrusions than other groups, irrespective of mood symptom severity.

    Conclusions:

    • Declarative memory impairments in juvenile BP-I mirror those observed in adult bipolar disorder, suggesting a potential trait marker.
    • These memory deficits appear to be trait-related rather than secondary to the current clinical state.
    • Heterogeneity in performance across BP-I, BP-II, and BP-NOS highlights the complexity of the juvenile bipolar disorder phenotype.