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Related Experiment Videos

Diffuse plane xanthomata.

Jennifer Bragg1

  • 1Department of Dermatology, New York University School of Medicine, USA.

Dermatology Online Journal
|January 13, 2006
PubMed
Summary
This summary is machine-generated.

This case study details diffuse plane xanthoma, a rare skin condition presenting as yellow-orange lesions. It highlights the importance of investigating underlying reticuloendothelial disorders despite normal lipid levels.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Diffuse plane xanthoma (DPX) is a rare xanthomatosis characterized by lipid deposition in the skin.
  • DPX can be associated with underlying systemic disorders, particularly reticuloendothelial malignancies.

Observation:

  • An 80-year-old woman presented with asymptomatic yellow-orange papules and plaques on her scalp, back, and arms.
  • Lesions on her back exhibited a Koebner reaction, indicating lesion development following skin trauma.
  • Clinical and histopathologic examination confirmed the diagnosis of diffuse plane xanthoma.

Findings:

  • Despite the characteristic skin lesions, laboratory tests revealed normal serum lipid levels.
  • An abnormal paraprotein was detected in the patient's blood, suggesting an underlying plasma cell dyscrasia.

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  • Bone marrow biopsy results were unremarkable, showing no evidence of malignancy.

    • Implications:

    • This case underscores that diffuse plane xanthoma can occur in the absence of hyperlipidemia, emphasizing the need for thorough systemic evaluation.
    • The presence of an abnormal paraprotein warrants further investigation for potential reticuloendothelial disorders, which may manifest years later.
    • Current treatment options for DPX are limited, with ablative lasers being a potential therapeutic modality.