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Related Experiment Videos

Colorectal carcinoma in children.

R A Brown1, H Rode, A J Millar

  • 1Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Journal of Pediatric Surgery
|July 1, 1992
PubMed
Summary

Pediatric colorectal carcinoma presents a diagnostic challenge, with delayed diagnosis and advanced disease contributing to poor outcomes in children. Early symptom recognition is crucial for improving survival rates in young patients with this rare cancer.

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Area of Science:

  • Pediatric Oncology
  • Gastrointestinal Oncology
  • Cancer Research

Background:

  • Colorectal carcinoma incidence is increasing in pediatric populations.
  • Diagnosis in children is often delayed, leading to advanced disease at presentation.
  • Malignant colorectal tumors in the young are frequently aggressive histological subtypes.

Purpose of the Study:

  • To report on a series of pediatric colorectal carcinoma cases.
  • To analyze factors contributing to poor prognosis in young patients.
  • To highlight the importance of timely diagnosis and awareness.

Main Methods:

  • Retrospective case series analysis of seven pediatric patients diagnosed with colorectal carcinoma.
  • Review of clinical presentation, diagnostic timelines, histological findings, and survival data.

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  • Correlation of diagnostic delay, disease stage, and histology with patient outcomes.

    • Main Results:

    • Average delay between symptom onset and diagnosis was 4.5 months.
    • Five of seven patients had distant metastases at initial diagnosis.
    • Malignant histology included mucin-secreting adenocarcinoma in five cases, a poor prognostic indicator.

    Conclusions:

    • Delayed diagnosis, advanced disease stage, and poorly differentiated histology are critical factors for poor prognosis in pediatric colorectal carcinoma.
    • Increased awareness and prompt medical evaluation of symptoms are essential for improving outcomes in children.
    • Further research into early detection strategies for pediatric colorectal cancer is warranted.