Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Identification of first candidate genes for creativity: a pilot study.

Martin Reuter1, Sarah Roth, Kati Holve

  • 1Department of Psychology, Justus-Liebig-University of Giessen, Otto-Behaghel-Str. 10F, D-35394 Giessen, Germany. martin.reuter@psychol.uni-giessen.de

Brain Research
|January 13, 2006
PubMed
Summary

Genetic variations in dopamine D2 receptor and TPH1 genes are linked to creativity. These genes explain 9% of creativity variance, with specific alleles influencing verbal and figural creativity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrafast complex-valued 4D fMRI reveals sleep-induced brain respiratory pulsation changes in both magnitude and phase signals.

NeuroImage·2025
Same author

Vasomics of the liver.

Gut·2025
Same author

Quo Vadis MRI?

Zeitschrift fur medizinische Physik·2025
Same author

Predicting closed quarters battle capability - Examining the influence of personality, attentional ability, 2D:4D-ratio and mindfulness on tactical performance.

Military psychology : the official journal of the Division of Military Psychology, American Psychological Association·2024
Same author

Frontal alpha asymmetry as a marker of approach motivation? Insights from a cooperative forking path analysis.

Journal of personality and social psychology·2024
Same author

High Wall Shear Stress Is Related to Complicated American Heart Association Lesion Type VI Plaques in Mild-to-Moderate ICA Stenosis: A 3D Cardiovascular MRI Study.

AJNR. American journal of neuroradiology·2024

Area of Science:

  • Behavioral Genetics
  • Molecular Psychiatry
  • Cognitive Neuroscience

Background:

  • Behavioral genetics indicates high heritability of intelligence, but identifying specific genes has been challenging.
  • Dopaminergic (DA) and serotonergic (5-HT) systems influence cognitive functions, with some DA metabolism genes linked to mental abilities.
  • Candidate genes specifically for creativity have not yet been identified.

Purpose of the Study:

  • To investigate the influence of catechol-O-methyltransferase (COMT VAL158MET), dopamine D2 receptor (DRD2 TAQ IA), and TPH1 (TPH-A779C) genes on creativity.
  • To control for intelligence while examining genetic associations with creativity.
  • To identify specific genetic markers associated with creativity and its subcomponents.

Main Methods:

Related Experiment Videos

  • A sample of 92 healthy Caucasian subjects was genotyped for COMT, DRD2, and TPH1.
  • Creativity was assessed, controlling for intelligence levels.
  • Statistical analyses were performed to determine associations between specific gene loci and creativity scores.

    • Main Results:

    • The DRD2 and TPH1 genes were significantly associated with total creativity, explaining 9% of the variance.
    • The COMT gene showed no significant relationship with creativity.
    • The A1+ allele of DRD2 was linked to higher verbal creativity, and the A allele of TPH1 was associated with higher figural and numeric creativity.

    Conclusions:

    • DRD2 and TPH1 genes are potential genetic markers for creativity.
    • These findings suggest that specific gene loci differentiate higher cortical functions, potentially related to hemispheric organization.
    • Further research is warranted to explore the precise mechanisms underlying these genetic influences on creativity.