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Updated: Aug 13, 2026

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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
Published on: October 3, 2014
Tissue engineering templates using minimal surfaces
Srinivasan Rajagopalan1, Bruce M Cameron, Richard A Robb
1Biomedical Imaging Resource, Mayo Clinic College of Medicine, Rochester, MN, USA.
Studies in Health Technology and Informatics
|January 13, 2006
Abstract:
The status quo of tissue engineering can be summarized as "a random walk through the design space". The existing scaffold designs based on computeraided design (CAD) and solid freeform fabrication (SFF) are anti-biomorphic and mechanically weak cubic partitions with sharp edges. We introduce minimal surface based unit cells to create biomorphic scaffolds with optimal stress/strain distribution and superior mechanical strength.

