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Updated: Aug 7, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 5, 2010
Life-threatening complications of extracorporeal treatment in patients with severe eosinophilia
W Gwinner1, J Menne, G Lonnemann
1Division of Nephrology, Department of Internal Medicine, Medical School Hannover, Hannover, Germany. wgwinner@t-online.de
Abstract:
We report three patients with massive eosinophilia of different etiology who developed bronchoconstriction, hypotension, and shock shortly after dialysis or leukapheresis had been begun. In two cases, ethylene oxide-free materials had been used ruling out an allergic reaction related to this compound. Degranulation of eosinophils with release of eosinophil peroxidase may have caused the observed adverse reactions, as suggested by in vitro experiments with blood from the three patients. Our observations draw attention to the fact that extracorporeal therapies may initiate life-threatening complications in patients with severe eosinophilia.
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