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Toward high-throughput drug screening using mass spectrometry.

Hans H Maurer1, Frank T Peters

  • 1Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, Homburg, Saar, Germany. hans.maurer@uniklinikum-saarland.de

Therapeutic Drug Monitoring
|January 13, 2006
PubMed
Summary

Mass spectrometry methods enable high-throughput screening for multiple drug classes in toxicology and doping control. These techniques, using gas or liquid chromatography-mass spectrometry, analyze urine and blood samples efficiently.

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Area of Science:

  • Analytical Chemistry
  • Forensic Science
  • Clinical Toxicology

Background:

  • High-throughput screening (HTS) is crucial for rapid analysis in clinical and forensic toxicology.
  • Mass spectrometry (MS) offers sensitive and specific detection capabilities for various compounds.
  • Current methods face challenges in simultaneously detecting multiple drug classes efficiently.

Purpose of the Study:

  • To critically evaluate mass spectrometry-based methods for high-throughput screening.
  • To discuss screening procedures for simultaneous detection of multiple drug classes.
  • To highlight applications in clinical toxicology, forensic toxicology, and doping control.

Main Methods:

  • Gas Chromatography-Mass Spectrometry (GC-MS) for volatile and semi-volatile compounds.

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  • Liquid Chromatography-Mass Spectrometry (LC-MS) for non-volatile and thermally labile compounds.
  • Development and optimization of multi-analyte detection protocols.

    • Main Results:

    • Mass spectrometry-based methods demonstrate significant potential for high-throughput analysis.
    • Simultaneous detection of diverse drug classes in biological matrices (urine, blood) is achievable.
    • GC-MS and LC-MS provide complementary capabilities for comprehensive screening.

    Conclusions:

    • Mass spectrometry offers a powerful platform for efficient, multi-drug class screening.
    • These methods are highly relevant for routine analysis in forensic toxicology and doping control.
    • Further optimization can enhance throughput and expand the scope of detectable drugs.