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[Familial intracranial aneurysms].

A S Kheĭreddin, Iu M Filatov, Sh Sh Eliava

    Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko
    |January 13, 2006
    PubMed
    Summary

    Screening first-degree relatives of patients with intracranial aneurysms can detect unruptured aneurysms. Early detection of familial aneurysms may reduce rupture risk and mortality rates.

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    Area of Science:

    • Neurology
    • Genetics
    • Public Health

    Context:

    • Intracranial aneurysms affect individuals and their families, with a notable familial aggregation.
    • Hemorrhage from ruptured aneurysms leads to high mortality and disability rates.
    • Familial intracranial aneurysms may rupture at a younger age compared to sporadic cases.

    Purpose:

    • To investigate the risk of intracranial aneurysms in first-degree relatives of affected patients.
    • To evaluate the efficacy of screening in detecting unruptured aneurysms within at-risk families.
    • To determine if early detection and intervention can mitigate adverse outcomes.

    Summary:

    • The study examined 38 patients with intracranial aneurysms and their relatives, categorizing relatives based on hemorrhage source.

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  • Relatives of patients with intracranial aneurysms showed a tendency for familial aneurysms to rupture at younger ages.
  • High mortality rates from intracranial bleeding were observed in relatives, highlighting the significance of familial risk.

    • Impact:

    • Screening first-order relatives of patients with a history of aneurysmal subarachnoid hemorrhage is crucial for detecting unruptured cerebrovascular aneurysms.
    • Early identification and treatment of asymptomatic aneurysms in at-risk individuals can significantly lower mortality and disability.
    • This approach aids in proactive management of aneurysmal disease within families.