Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remdesivir Use During Pregnancy: Findings From the Prospective COVID-19 International Drug Pregnancy Registry and Narrative Literature Review.

Journal of pregnancy·2026
Same author

Lessons Learned From the COVID-19 Vaccines International Pregnancy Exposure Registry: Insights for Designing and Implementing Global Pregnancy Safety Studies.

Birth defects research·2026
Same author

Systemic lupus erythematosus and pregnancy: a comprehensive clinical review of maternal, fetal, and treatment considerations.

Advances in rheumatology (London, England)·2026
Same author

Non-alcoholic Fatty Liver Disease in Pregnancy: Clinical Implications, Adverse Outcomes, and Therapeutic Considerations.

Journal of clinical and experimental hepatology·2026
Same author

Pregnancy and Multiple Sclerosis: A Narrative Review of Clinical Outcomes, Disease Activity, and Treatment Considerations.

Multiple sclerosis and related disorders·2025
Same author

Efficacy and safety of casirivimab/imdevimab (REGEN-COV) in pregnant individuals with COVID-19: Literature review and insights from the COVID-19 International Drug Pregnancy Registry.

Obstetric medicine·2025

Related Experiment Video

Updated: Jul 9, 2026

Quantification of Orofacial Phenotypes in Xenopus
09:26

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

Oral clefts with associated anomalies: methodological issues.

Diego F Wyszynski1, Andrea Sárközi, Andrew E Czeizel

  • 1Boston University School of Medicine, Massachusetts 02118, USA.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|January 13, 2006
PubMed
Summary

Prevalence rates for oral cleft anomalies vary widely due to inconsistent study methods. Factors like case definitions, examination timing, and ascertainment influence reported frequencies of these birth defects.

More Related Videos

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

Related Experiment Videos

Last Updated: Jul 9, 2026

Quantification of Orofacial Phenotypes in Xenopus
09:26

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

Area of Science:

  • Medical Genetics
  • Birth Defects Research
  • Epidemiology

Background:

  • Oral clefts are common congenital anomalies.
  • Associated anomalies significantly impact patient outcomes.
  • Reported prevalence rates for these anomalies show considerable variation.

Purpose of the Study:

  • To identify and discuss methodological factors contributing to the wide variation in reported prevalence rates of anomalies associated with oral clefts.
  • To provide a framework for understanding discrepancies in oral cleft anomaly research.

Main Methods:

  • Literature review and synthesis of existing studies on oral cleft anomalies.
  • Analysis of methodological differences across published prevalence data.
  • Identification of key factors influencing ascertainment and reporting.

Main Results:

  • Significant heterogeneity exists in case definitions and inclusion/exclusion criteria.
  • Variability in the timing of post-birth examination affects anomaly detection.
  • Differences in clinical expression, diagnostic technology, and patient ascertainment contribute to prevalence variations.

Conclusions:

  • Discrepancies in published oral cleft anomaly prevalence are primarily methodological.
  • Standardization of case definitions and examination protocols is crucial.
  • Acknowledging population differences and temporal changes is essential for accurate prevalence estimation.