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Pravastatin-induced lichenoid drug eruption.
Vernon Sc Pua1, Richard A Scolyer, Ross Stc Barnetson
1Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
The Australasian Journal of Dermatology
|January 13, 2006
Summary
A 64-year-old woman developed pigmented macules due to pravastatin, a statin medication. Stopping the drug led to the gradual fading of skin pigmentation, confirming a lichenoid drug eruption.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Lichenoid drug eruptions are hypersensitivity reactions to medications.
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are commonly prescribed for hyperlipidemia.
- Previous reports suggest statins can induce lichenoid drug eruptions.
Observation:
- A 64-year-old female patient presented with widespread, numerous pigmented macules on her face and upper back.
- Skin biopsy revealed a lichenoid dermatitis pattern.
Findings:
- Pravastatin was identified as the most probable causative agent for the observed skin reaction.
- Discontinuation of pravastatin therapy resulted in a progressive resolution of the skin pigmentation.
Implications:
- This case highlights pravastatin as a potential cause of lichenoid drug eruptions.
- Physicians should consider statins in the differential diagnosis of drug-induced lichenoid dermatitis.
- Awareness of statin-induced skin reactions is crucial for patient management.