Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glutamate receptors: variation in structure-function coupling.

Anders S Kristensen1, Matthew T Geballe, James P Snyder

  • 1Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322-3090, USA. ask@pharm.emory.edu

Trends in Pharmacological Sciences
|January 13, 2006
PubMed
Summary

Glutamate receptors in the central nervous system (CNS) mediate fast synaptic transmission. Recent structural insights reveal diverse mechanisms for how these receptors couple agonist binding to channel opening, despite shared features.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor" [Molecular Pharmacology 108 (2026) 100104].

Molecular pharmacology·2026
Same author

Gene Portals: A Framework for Integrating Clinical, Functional, and Structural Evidence into Rare Disease Variant Classification.

medRxiv : the preprint server for health sciences·2026
Same author

Claudin 24-A novel enhancer of AMPA receptor fidelity.

Science advances·2026
Same author

A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor.

Molecular pharmacology·2026
Same author

Correction: GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy.

Molecular psychiatry·2026
Same author

Memantine treatment in individuals with GRIN gain-of-function variants is associated with improvements in behavior, development, and seizure frequency.

Epilepsia·2026

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Fast excitatory synaptic transmission in the CNS is primarily mediated by glutamate and its associated ion channel receptors.
  • Understanding the relationship between neurotransmitter binding and receptor activation is crucial for neuroscience.

Purpose of the Study:

  • To explore the mechanisms by which glutamate receptors translate agonist binding into channel opening.
  • To highlight recent advancements in understanding receptor function based on structural data.

Main Methods:

  • Analysis of recent structural information concerning the agonist-binding sites of glutamate receptor family members.
  • Comparative studies of different glutamate receptor subtypes.

Main Results:

Related Experiment Videos

  • Significant progress in understanding receptor activation has been made in the last five years, driven by new structural data.
  • Despite structural similarities among glutamate receptor family members, distinct mechanisms for coupling agonist binding to channel opening have been identified.

Conclusions:

  • The diverse mechanisms of action among glutamate receptor subtypes underscore the complexity of synaptic transmission.
  • Further structural and functional studies are needed to fully elucidate these distinct activation pathways.