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Simultaneous coinfection by multiple strains during Burkholderia cepacia complex infection in cystic fibrosis

Jeffrey H Yang1, Theodore Spilker, John J LiPuma

  • 1Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA.

Diagnostic Microbiology and Infectious Disease
|January 13, 2006
PubMed

Insights

Cystic fibrosis (CF) patients with Burkholderia cepacia complex (Bcc) respiratory infections usually harbor a single Bcc strain. Multiple strain infections are rare, potentially occurring more often early in the infection course.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pulmonary Medicine

Background:

  • The natural history of Burkholderia cepacia complex (Bcc) respiratory tract infections in cystic fibrosis (CF) patients is not fully understood.
  • It remains unclear if CF patients with Bcc infections are typically colonized by a single Bcc strain or multiple strains.

Purpose of the Study:

  • To investigate the strain diversity of Burkholderia cepacia complex (Bcc) in respiratory tract infections among individuals with cystic fibrosis (CF).
  • To determine whether chronic Bcc infection in CF patients involves a single strain or multiple strains.

Main Methods:

  • Genotyping of 912 Bcc isolates.
  • Analysis of isolates recovered from sputum cultures of over 100 CF patients.

Main Results:

  • Chronic Bcc infection in CF patients generally involves a single predominant strain.
  • Infrequent transient coinfection with multiple Bcc strains was observed.
  • Multiple strain infections may be more prevalent in the early stages of Bcc infection.

Conclusions:

  • Chronic Burkholderia cepacia complex infections in cystic fibrosis patients are typically caused by a single strain.
  • The occurrence of multiple Bcc strains during infection is infrequent and may be transient, particularly early in the infection timeline.

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