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11Beta-hydroxysteroid dehydrogenase type 1--a role in inflammation?
Karen E Chapman1, James S Gilmour, Agnes E Coutinho
1Endocrinology Unit, Centre for Cardiovascular Sciences, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Karen.Chapman@ed.ac.uk
Molecular and Cellular Endocrinology
|January 13, 2006
Summary
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regulates active glucocorticoids. This review highlights recent evidence on 11beta-HSD1
Area of Science:
- Endocrinology
- Immunology
- Molecular Biology
Background:
- Glucocorticoids possess significant anti-inflammatory properties and modulate immune responses.
- Endogenous glucocorticoids are critical regulators of both innate and adaptive immunity.
- 11beta-hydroxysteroid dehydrogenase enzymes control glucocorticoid activity.
Purpose of the Study:
- To review the role of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in immune responses.
- To elucidate the function of 11beta-HSD1 in inflammation.
Main Methods:
- Review of recent scientific literature.
- Analysis of evidence on 11beta-HSD1 activity and its impact on inflammatory processes.
Main Results:
- 11beta-HSD1 converts inactive glucocorticoids to active forms, enhancing intracellular receptor availability.
- Emerging evidence indicates a significant role for 11beta-HSD1 in modulating inflammatory responses.
- The precise function of 11beta-HSD1 in immunity was previously unclear but is now gaining attention.
Conclusions:
- 11beta-HSD1 is a key regulator of glucocorticoid action within the immune system.
- Further research into 11beta-HSD1's role in inflammation may reveal new therapeutic targets.