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Related Experiment Videos

Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast

Alphonse G Taghian1, Kevin R Kozak, Karen P Doppke

  • 1Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA. ataghian@partners.org

International Journal of Radiation Oncology, Biology, Physics
|January 13, 2006
PubMed
Summary

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This summary is machine-generated.

Three-dimensional conformal radiation therapy (3D-CRT) for accelerated partial-breast irradiation (APBI) provides excellent target coverage and spares normal tissues. This technique may expand access to APBI for early-stage breast cancer patients.

Area of Science:

  • Radiation Oncology
  • Breast Cancer Treatment
  • Medical Physics

Background:

  • Accelerated partial-breast irradiation (APBI) is an evolving treatment for early-stage breast cancer.
  • Various APBI techniques are under investigation to optimize treatment delivery and outcomes.
  • Three-dimensional conformal radiation therapy (3D-CRT) offers precise radiation targeting.

Purpose of the Study:

  • To evaluate the initial clinical experience with 3D-CRT for APBI in early-stage breast cancer patients.
  • To assess the dosimetric characteristics and feasibility of this 3D-CRT APBI technique.

Main Methods:

  • Sixty-one early-stage breast cancer patients with small tumors and no nodal involvement were treated with 3D-CRT APBI.
  • The prescribed dose was 32 Gy in 4-Gy fractions, delivered twice daily.

Related Experiment Videos

  • Treatment planning focused on minimizing beams for adequate planning target volume (PTV) coverage.

    • Main Results:

    • A combination of photons and electrons was used in 85% of patients, often with a three-field technique.
    • Mean PTV coverage was high (93% +/- 7% for 100% dose).
    • Dose inhomogeneity was minimal (11%), with low mean doses to the ipsilateral lung (1.8 Gy) and heart (0.8 Gy).

    Conclusions:

    • Simple 3D-CRT techniques can achieve adequate PTV coverage in APBI.
    • This method demonstrates significant normal-tissue sparing.
    • 3D-CRT APBI may enhance the accessibility of partial breast irradiation for suitable breast cancer patients.