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Updated: Aug 13, 2026
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Effect of curcumin on the expression of LDL receptor in mouse macrophages
Chunlei Fan1, Xingde Wo, Ying Qian
1Institute of Molecular Medicine, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053, China. taijispear@126.com
Abstract:
To investigate the molecular mechanisms of lipid-lowering drug, Rhizoma Curcumae Longae, we treated the mouse macrophages with curcumin, which was purified from the ethanol extraction of Rhizoma Curcumae Longae. The LDL receptors expressed in the macrophages were determined by ELISA, FLISA and assay of LDL uptake. Here for the first time, we found that curcumin obviously up-regulated the expression of LDL receptor in mouse macrophages, and the dose-effect relationship was demonstrated.
