Related Experiment Video
Updated: Aug 13, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)
Published on: January 20, 2016
Interaction of bulged DNA with leucine-containing mimics of NCS-chrom
Zhen Xi1, Di Ouyang, Hong-Tao Mu
1Institute of Elemento-Organic Chemistry and Department of Chemical Biology, Nankai University, Tianjin 300071, China. zhenxi@nankai.edu.cn
Abstract:
Synthesis of chiral spirocyclic helical compounds containing leucine that mimic the molecular architecture of the potent DNA bulge binder obtained from the natural product metabolite NCSi-gb has been accomplished. The interaction between the compounds and DNA was studied by circular dichroism (CD) method. The results suggested that the two synthetic diastereoisomers specifically targeted the bulge site of DNA and induced conformational change of bulged DNA greatly.
Related Concept Videos
Single-Strand DNA Binding Proteins
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Cooperative Binding of Transcription Regulators
