Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modeling mitosis.

Alex Mogilner1, Roy Wollman, Gul Civelekoglu-Scholey

  • 1Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, CA 95616, USA. mogilner@math.ucdavis.edu

Trends in Cell Biology
|January 13, 2006
PubMed
Summary

Mathematical models and simulations, alongside experiments, illuminate the mitotic spindle

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CIPHER: An end-to-end framework for designing optimized aggregated spatial transcriptomics experiments.

PLoS computational biology·2026
Same author

Nonuniform filament turnover, contractility, and bundle formation in disordered actomyosin networks.

Biophysical journal·2026
Same author

Reconstructing Actin Dynamics of the Leading Edge from Observational Data.

bioRxiv : the preprint server for biology·2026
Same author

The kinetochore corona orchestrates chromosome congression through transient microtubule interactions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

CIPHER: An end-to-end framework for designing optimized aggregated spatial transcriptomics experiments.

bioRxiv : the preprint server for biology·2026
Same author

Reconstructing noisy gene regulation dynamics using extrinsic-noise-driven neural stochastic differential equations.

PLoS computational biology·2025

Area of Science:

  • Cell Biology
  • Biophysics
  • Computational Biology

Background:

  • The mitotic spindle is a complex protein machine essential for accurate cell division.
  • Understanding its molecular mechanisms requires integrating experimental data with theoretical approaches.

Purpose of the Study:

  • To review recent mathematical models and computer simulations of mitotic spindle functions.
  • To explain the molecular mechanisms underlying spindle assembly, chromosome segregation, and cell cycle checkpoints.

Main Methods:

  • Review of existing literature on mathematical modeling and computer simulations of the mitotic spindle.
  • Integration of modeling insights with experimental findings in cell biology.

Main Results:

  • Models successfully explain spindle assembly, chromosome capture and congression, and spindle positioning.
  • Simulations provide insights into the dynamics of microtubules and motor proteins.
  • The spindle assembly checkpoint mechanisms are elucidated through modeling approaches.

Conclusions:

  • Mathematical modeling and simulations are powerful tools for understanding the mitotic spindle.
  • Further development of system-level models is needed to capture the complexity of mitosis.
  • Continued integration of computational and experimental approaches will advance the field.

Related Experiment Videos