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Antiinflammatory activity of Sambucus ebulus hexane extracts
M A Ebrahimzadeh1, M Mahmoudi, E Salimi
1Department of Medicinal Chemistry, School of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran. zadeh20@yahoo.com
Fitoterapia
|January 13, 2006
Summary
Hexane extracts from Sambucus ebulus aerial parts and roots show significant anti-inflammatory effects in rats, inhibiting edema. Leaf extracts were inactive, and no toxicity was observed in mice.
Area of Science:
- Pharmacology and Ethnobotany
- Natural Product Chemistry
Background:
- Sambucus ebulus, commonly known as elderberry, has traditional uses suggesting anti-inflammatory properties.
- Investigating plant-derived compounds for therapeutic potential is crucial for developing new anti-inflammatory agents.
Purpose of the Study:
- To evaluate the anti-inflammatory activity of hexane extracts from different parts of Sambucus ebulus.
- To determine the dose-dependent effects and safety profile of these extracts in animal models.
Main Methods:
- Hexane extracts of aerial parts, leaves, and roots of Sambucus ebulus were prepared.
- Anti-inflammatory activity was assessed using carrageenan-induced edema in rats.
- Toxicity was evaluated in mice following intraperitoneal injection.
Main Results:
- Extracts from aerial parts and roots demonstrated statistically significant, dose-dependent inhibition of edema.
- Leaf extracts showed no significant anti-inflammatory activity up to 600 mg/kg.
- Aerial parts and root extracts at 600 mg/kg inhibited edema by approximately 80%, comparable to diclofenac.
Conclusions:
- Hexane extracts of Sambucus ebulus aerial parts and roots possess potent anti-inflammatory properties.
- The leaf extract does not exhibit significant anti-inflammatory activity.
- Sambucus ebulus extracts demonstrated a favorable safety profile with no observed toxicity.