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Updated: Aug 13, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
Renewing the T cell repertoire to arrest autoimmune aggression
Paolo A Muraro1, Daniel C Douek
1Neuroimmunology Branch, NINDS/NIH, Bldg. 10, Room 5B16, 10 Center Drive, MSC1400, Bethesda, MD 20892-1400, USA. murarop@ninds.nih.gov
Abstract:
There is now evidence that high-dose immune ablation and autologous hematopoietic stem cell transplantation in humans triggers a reconstitution program that leads to the comprehensive renewal of the T cell repertoire. We argue here that several features of this program help to explain how autologous hematopoietic stem cell transplantation can induce long-term clinical remission from organ-specific-, as well as systemic, autoimmune diseases. We propose a model envisioning a coordinated sequence of events, rebuilding an immune system that is competent against infection but that is substantially reconfigured in a way that is less likely to redevelop autoimmunity.
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