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Central muscarinic receptor subtypes regulating voiding in rats
Masanori Kono1, Yasuo Nakamura, Yoshiyuki Ishiura
1Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
The Journal of Urology
|January 13, 2006
Summary
Central muscarinic M1 and M3 receptor antagonists inhibit urination in rats, while M2 and M4 antagonists cause excitatory changes. This study clarifies muscarinic receptor roles in voiding regulation.
Area of Science:
- Neuroscience
- Urology
Background:
- Muscarinic receptors are widely distributed in the brain.
- Central muscarinic receptors play a role in regulating urination.
- The specific roles of individual muscarinic receptor subtypes in voiding control remain unclear.
Purpose of the Study:
- To investigate the effects of selective muscarinic M1-M4 receptor antagonists on rat voiding function.
- To elucidate the distinct roles of muscarinic receptor subtypes in central micturition control.
Main Methods:
- Intracerebroventricular administration of selective muscarinic M1-M4 receptor antagonists (pirenzepine, methoctramine, pFHHSiD, MT-3) in female Sprague-Dawley rats.
- Cystometry to measure bladder capacity (BC) and maximal voiding pressure.
- Urethral pressure profile (UPP) measurement.
Main Results:
- Muscarinic M1 and M3 receptor antagonists increased bladder capacity and urethral pressure, while decreasing maximal voiding pressure.
- Muscarinic M2 and M4 receptor antagonists decreased bladder capacity and maximal voiding pressure.
- No significant changes in minimal UPP were observed with M2 and M4 antagonists.
Conclusions:
- Intracerebroventricular M1 and M3 receptor antagonism inhibits urination in rats.
- Intracerebroventricular M2 and M4 receptor antagonism induces excitatory changes in voiding function.
- This research differentiates the roles of muscarinic receptor subtypes in the central regulation of micturition.