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Related Experiment Videos

Disposition of BDE 47 in developing mice.

Daniele F Staskal1, Janet J Diliberto, Linda S Birnbaum

  • 1UNC Curriculum in Toxicology, USA. dstaskal@chemrisk.com

Toxicological Sciences : an Official Journal of the Society of Toxicology
|January 13, 2006
PubMed
Summary

Infants and young children accumulate higher concentrations of 2,2

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Area of Science:

  • Environmental Science
  • Toxicology
  • Developmental Biology

Background:

  • 2,2',4,4'-tetrabromodiphenyl ether (BDE 47) is a prevalent polybrominated diphenyl ether congener in North America.
  • Infants and young children face the highest exposure risks due to BDE 47, with potential adverse developmental effects noted in rodent studies.

Purpose of the Study:

  • To investigate the disposition of BDE 47 in susceptible infantile mice.
  • To examine the disposition and excretion of BDE 47 across various developmental stages in mice.

Main Methods:

  • Radiolabeled (14)C-BDE 47 was administered orally to C57BL/6 mice at different developmental stages.
  • The disposition and excretion of BDE 47 were monitored following a single oral dose (1 mg/kg).

Main Results:

  • Toxicokinetics of BDE 47 differ between developing and adult mice.
  • Developing mice exhibit higher BDE 47 concentrations due to a reduced excretion capacity.
  • Elevated BDE 47 levels in pups occur during critical developmental periods.

Conclusions:

  • Developing mice show altered BDE 47 toxicokinetics compared to adults.
  • Reduced excretion capacity in pups leads to higher BDE 47 accumulation during development.
  • This accumulation poses risks to target tissues during critical developmental windows.

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