Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Canine intraneural perineurioma.

R J Higgins1, P J Dickinson, D F Jimenez

  • 1Department of Pathology, Immunology and Pathology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA. rjhiggins@ucdavis.edu

Veterinary Pathology
|January 13, 2006
PubMed
Summary

A German Shepherd Dog experienced progressive leg weakness due to an intraneural perineurioma, a rare nerve sheath tumor. This case highlights the importance of advanced imaging and histology for diagnosing canine peripheral nerve tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues.

Journal of neuro-oncology·2024
Same author

The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues.

Research square·2024
Same author

Tumor Biology as Predictor of Mortality in Liver Transplantation for Hepatocellular Carcinoma.

Transplantation proceedings·2018
Same author

Liver Transplantation in Hepatitis C-Infected Patients: Experience From a South American Transplant Center.

Transplantation proceedings·2018
Same author

Dynamical analysis for a scalar-tensor model with Gauss-Bonnet and non-minimal couplings.

The European physical journal. C, Particles and fields·2017
Same author

Expression and targeting of transcription factor ATF5 in dog gliomas.

Veterinary and comparative oncology·2017

Area of Science:

  • Veterinary Neurology
  • Canine Pathology
  • Neoplastic Disease

Background:

  • Peripheral nerve sheath tumors are uncommon in dogs.
  • Intraneural perineuriomas are a rare subtype, originating from perineurial cells.

Observation:

  • A 6-year-old German Shepherd presented with progressive, nonpainful left pelvic limb paresis.
  • Magnetic resonance imaging (MRI) showed muscle atrophy and an enlarged L5 spinal nerve.
  • Surgical exploration revealed thickened L5 and L6 nerve roots.

Findings:

  • Histopathology confirmed distended fascicles with neoplastic perineurial cells forming pseudo-onion bulbs.
  • Immunohistochemistry showed perineurioma cells were negative for S-100 and collagen IV, but positive for laminin.
  • Ultrastructural analysis revealed characteristic perineurial cell processes and desmosomal junctions.

Related Experiment Videos

Implications:

  • This case provides detailed morphologic and immunologic data on canine intraneural perineurioma.
  • The findings help differentiate this tumor from other neuropathies, such as hypertrophic neuropathy.
  • Accurate diagnosis is crucial for appropriate management of peripheral nerve tumors in dogs.